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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Neuropharmacology. 2019 Mar 14;151:180–188. doi: 10.1016/j.neuropharm.2019.03.020

Figure 2.

Figure 2.

Effects of nalbuphine (left panels) and buprenorphine (right panels) on ICSS frequency-rate curves in rats before (top panels) and after (bottom panels) seven-day treatment with 10 mg/kg/day nalbuphine or 0.032 mg/kg/day buprenorphine, respectively. Abscissae: electrical brain stimulation frequency in Hertz (Hz, log scale). Ordinates: ICSS reinforcement rate expressed as a percentage of the maximum control rate (% MCR). Filled symbols indicate statistical significance (p<0.05) as compared to saline. All points show mean ± S.E.M. for n=6 rats.