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Effects of morphine on ICSS frequency-rate curves in rats following the second dose-effect determination for a given drug after seven-day treatments as indicated in Table 1. Abscissae: electrical brain stimulation frequency in Hertz (Hz, log scale). Ordinates: ICSS reinforcement rate expressed as a percentage of the maximum control rate (% MCR). Filled symbols indicate statistical significance (p<0.05) as compared to saline. All points show mean ± S.E.M. for n=6 rats.
