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Relationship between MOR agonist efficacy and effects on ICSS. MOR agonists tested in this study range in efficacy from methadone at the high end to NAQ at the low end of the efficacy continuum. A-Efficacy range to produce ICSS depression in opioid-naïve rats. B-Efficacy range to trigger adaptations that promote opioid-induced ICSS facilitation after repeated treatment. C-Efficacy range to facilitate ICSS in rats already sensitized to opioid-induced ICSS facilitation.
