Figure 2.

Approaches for enhancing intratumoral chimeric antigen receptor (CAR) T‐cell infiltration. Commonly, the chemokine receptors endogenously expressed by CAR T cells do not match the chemokines present in the tumor microenvironment. (a) One approach to improve CAR T‐cell infiltration therefore is to transduce them with chemokine receptors such as CXCR2, CCR2b or CCR4, better matching the chemokine profile of the tumor microenvironment. (b) Alternatively, both PD‐1‐blockade and epigenetic modifiers, EZH2 and GSK126, have been shown to increase intratumoral expression of chemokines CXCL9 and CXCL10, leading to enhanced CXCR3‐dependent trafficking of adoptively transferred T cells.