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. 2019 Apr 30;12:3245–3254. doi: 10.2147/OTT.S202271

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© 2019 Shao et al.

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Mechanisms of Annexin A1 in inflammation. Annexin A1, glucocorticoid-induced synthesis in neutrophils, activates the MAPK/ERK signaling pathway through FPRs and reduces neutrophil activity to inhibit inflammatory responses. Externalization of Annexin A1 promotes clearance of apoptotic cells and stimulates T cell proliferation and differentiation, contrary to the action of glucocorticoids. ICAM1 was released through endothelial cells induced by cleaved Annexin A1 to enhance the transendothelial migration capacity of neutrophils and promote the inflammatory response.