Table 1.
Anti-inflammatory and pro-inflammatory roles of Annexin A1
| Source of Annexin A1 | Disease model | Effects observed | Suggested role of Annexin A1 | Reference |
|---|---|---|---|---|
| Endogenous | ||||
| Annexin A1−/- mice | Arthritis | Deficiency of Annexin A1 also abrogated glucocorticoid-dependent inhibition of cytokine and chemokine gene expression in the inflamed synovium | Anti-inflammatory | 126 |
| Annexin A1−/- mice | EAE | Decreased signs of the disease and reduced infiltration of T cells in the spinal cord | Pro-inflammatory | 127 |
| Annexin A1−/- mice | Endotoxaemia | LPS generated a deregulated cellular and cytokine response with a marked degree of leukocyte adhesion in the microcirculation | Anti-inflammatory | 74 |
| Annexin A1−/- mice | DSS-induced colitis | Annexin A1 is a role in the protective and reparative properties of the intestinal mucosal epithelium | Anti-inflammatory | 25 |
| Annexin A1−/- mice | NASH | Increased macrophage recruitment and exacerbation | Anti-inflammatory | 128 |
| Exogenous | ||||
| WKYMVm-NH2 | IAV | Agonist WKYMVm-NH2 decreased survival and increased viral replication and inflammation after IAV infection | Pro-inflammatory | 88 |
| Ac2-26 | Cardiovascular disease | Blockade of leukocyte recruitment, decreasing vascular permeability | Anti-inflammatory | 68 |
| Annexin A1 | Pleurisy | Inducing neutrophil apoptosis and increasing efferocytosis by macrophages | Anti-inflammatory | 129 |
| Ac2-26 | Intestinal mucosal inflammation | Accelerated healing of murine colonic wounds after biopsy-induced injury and recovery following experimentally induced colitis |
Anti-inflammatory | 130 |
| Annexin A1 | SJS and TEN | Annexin A1-FPR1 interaction contributes to necroptosis of keratinocytes | Pro-inflammatory | 131 |
| Annexin A1 | RA | Treatment of RA patients with steroid decreased Annexin A1 expression in T cells, GCs suppress Annexin A1 expression in T cells | Anti-inflammatory | 132 |
| Ac2-26 or Annexin A1 | Atherosclerotic lesions | Increased myeloid cells recruitment via Annexin A1/FPR2 signaling | Anti-inflammatory | 133 |
| Ac2-26 or Annexin A1 | MI | Against myocardial I-R injury, limiting neutrophil infiltration, preserving cardiomyocyte viability and contractile function | Anti-inflammatory | 69 |
Notes: Ac2–26: N-terminal fragment of Annexin A1 (residues 2–26); WKYMVm-NH2: N-terminal fragment of Annexin A1 (residues 1–6).
Abbreviations: EAE, experimental autoimmune encephalomyelitis; DSS-induced colitis, dextran sulfate sodium(DSS)-induced colitis; NASH, nonalcoholic steatohepatitis; IAV, influenza A virus; SJS, Stevens-Johnson syndrome; TEN, toxic epidermal necrolysis; RA, rheumatoid arthritis; MI, Myocardial infarction.