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. 2019 Apr 29;12:3181–3196. doi: 10.2147/OTT.S193097

Figure 4.

Figure 4

TP53INP1 is a direct target of miR-155-5p. (A). Predicted miR-155-5p target sequences in 3ʹ-UTR of TP53INP1. (B). Luciferase activity of TP53INP1 (wild type or mutant type) was evaluated after miR-155-5p transfection into HEK-293T cell. ** P<0.01, compared to miR-NC. (C). The levels of TP53INP1 were detected by qRT-PCR assay in cervical cancer cell lines and human cervical surface epithelial cell line, HcerEpic. (D). The levels of TP53INP1 in cervical cancer tissues and paratumor tissues were measured by qRT-PCR. (E). The level of miR-155-5p was negative with the level of TP53INP1 in cervical cancer tissues. (F). The level of TP53INP1 in SiHa cell that was transfected with miR-NC inhibitor or miR-155-5p inhibitor was measured by western blotting. (G). The expression level of TP53INP1 in CaSki cell that was transfected with miR-155-5p or miR-NC was measured by western blotting assay.