TABLE 2.
Comparison of models for GWS hits1
| Whole body lean mass | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Model 1 (n = 85,519) | Model 2 (n = 85,519) | Model 3 (n = 85,519) | ||||||||||||
| SNP ID | Chr | Position | Gene | A1/A2 | AF 1 | β | SE | P | β | SE | P | β | SE | P |
| rs2943656 | 2 | 226,830,162 | IRS1 | A/G | 0.37 | –0.04 | 0.03 | 9.1 × 10−2 | –0.11 | 0.02 | 7.4 × 10−6 | –0.14 | 0.02 | 1.5 × 10−11 |
| rs9991501 | 4 | 88,477,507 | HSD17B11 | T/C | 0.04 | –0.46 | 0.08 | 1.6 × 10−8 | –0.48 | 0.08 | 7.3 × 10−10 | –0.39 | 0.07 | 5.8 × 10−9 |
| rs2287926 | 5 | 82,851,164 | VCAN | A/G | 0.13 | 0.12 | 0.04 | 3.2 × 10−3 | 0.17 | 0.04 | 6.2 × 10−6 | 0.19 | 0.03 | 7.5 × 10−9 |
| rs4842924 | 15 | 82,378,611 | ADAMTSL3 | T/C | 0.52 | –0.08 | 0.03 | 2.3 × 10−3 | –0.12 | 0.02 | 9.7 × 10−7 | –0.12 | 0.02 | 1.4 × 10−8 |
| rs9936385 | 16 | 52,376,670 | FTO | T/C | 0.61 | –0.32 | 0.03 | 1.8 × 10−30 | –0.24 | 0.03 | 2.4 × 10−20 | –0.14 | 0.02 | 1.4 × 10−9 |
| rs10871777 | 18 | 56,002,743 | MC4R | A/G | 0.76 | –0.28 | 0.03 | 1.0 × 10−18 | –0.21 | 0.03 | 4.2 × 10−13 | –0.12 | 0.03 | 6.2 × 10−7 |
| rs733381 | 22 | 38,999,594 | TNRC6B | A/G | 0.79 | 0.19 | 0.03 | 5.2 × 10−9 | 0.20 | 0.03 | 4.6 × 10−11 | 0.15 | 0.03 | 5.5 × 10−9 |
1Model 1: not adjusted for fat; Model 2: adjusted for fat mass as a percentage of body mass; Model 3: adjusted for fat mass in kilograms. P < 5 × 10−8 is significant. AF, allele frequency; Chr, chromosome; SNP, single nucleotide polymorphism.