TABLE 4.

Associations of lean mass increasing alleles with musculoskeletal phenotypes¹

						Cross-phenotype
SNP	LM IA	Gene	Effect in M1	M1/M3 ratio, %	Type of locus	Grip strength	FN-BMD	LS-BMD	Fx
rs9936385	C	FTO	Yes	234	Sumo Wrestler	0	0	0	– –
rs10871777	G	MC4R	Yes	222	Sumo Wrestler	0	0	0	0
rs733381	A	TNRC6B	Yes	125	Intermediate	++	0	– –	+
rs9991501	C	HSD17B11	Yes	120	Intermediate	0	0	+	0
rs2287926	A	VCAN	Yes	64	Body Builder	0	0	0	0
rs4842924	C	ADAMTSL3	Yes	67	Body Builder	++	0	0	0
rs2943656	G	IRS1	No	NA	Indirect/Fat locus	0	0	0	0

¹The threshold for a statistically significant association with Bonferroni correction for 4 traits is P = 0.0125 (0.05/4). For further details, see Supplemental Table 8. +, nominal significant increase; ++, multiple testing corrected significant increase; – –, multiple testing corrected significant decrease; 0, no significant effect; BMD, bone mineral density; FN, femoral neck; Fx, fracture; LM IA, lean mass increasing allele; LS, lumbar spine; M1, Model 1 not adjusted for fat; M3, Model 3 adjusted for fat mass in kilograms; M1/M3 ratio, a measure of the degree of attenuation of the lean mass association after fat mass adjustment; NA, not applicable because no effect in M1.