Table 1.
Demographics and clinical characteristics of participants included in 7T MRI analysis.
| HC | PD | p | |
|---|---|---|---|
| Total | 8 | 29 | |
| Age, y | 67.9 ± 6.8 (57–76) | 65.5 ± 7.8 (52–79) | .41 |
| Female, n (%)† | 5 (62.5%) | 15 (51.7%) | .23 |
| Education, y | 17.3 ± 2.1 (14–20) | 16.7 ± 2.7 (12−20) | .58 |
| Disease duration, y | n/a | 4.5 ± 3.0 (1–15) | |
| n (%) PD 0–5 y | 19 (65.5%) | ||
| n (%) PD 6–10 y | 9 (31.0%) | ||
| n (%) PD 11–16 y | 1 (3.5%) | ||
| MDS-UPDRS-III (Off) | n/a | 33.7 ± 13.6 (6–62) | |
| Cognitive diagnosis | |||
| n (%) NC | 8 (100%) | 18 (62.1%) | |
| n (%) PD-MCI | 8 (27.6%) | ||
| n (%) PDD | 3 (10.3%) | ||
| MoCA†† | 27.6 ± 2.2 (24–29) | 25.5 ± 3.9 (14–29) | .14 |
| CVLT†† | |||
| Immediate memory | 10.9 ± 2.4 (7–15) | 9.1 ± 3.8 (0–15) | .23 |
| Delayed memory | 11.8 ± 2.3 (9–16) | 9.4 ± 4.6 (0–16) | .22 |
| Delayed cued memory | 12.4 ± 1.5 (10–16) | 11.0 ± 3.7 (2–16) | .36 |
| Learning | 51.6 ± 4.7 (45–59) | 44.8 ± 12.6 (14–67) | .15 |
Mean ± SD (range).
Abbreviations: y = years, MDS-UPDRS-III = Movement Disorders Society Unified Parkinson's Disease Rating Scale, part III (motor exam), n (%) PD = number (percent) of Parkinson's disease participants with a disease duration in that range, n (%) NC = number (percent) of participants with cognition in the normal range, n (%) PD-MCI = number (percent) of Parkinson's disease participants with mild cognitive impairments, n (%) PDC = number (percent) of Parkinson's disease participants dementia, n/a = not applicable.
All between group p-values represent t-tests, except where indicated by † for Pearson χ2 test between dichotomous variable, †† for Mann–Whitney U for continuous variables with unequal variance.