Table 3.
Brain regions showing significant functional connectivity changes (post-treatment minus pre-treatment) with right hippocampus and bilateral ACC as seeds.
| Immediate Memory |
Delayed Memory |
Delayed Cued Memory |
|
|---|---|---|---|
| r (p) | r (p) | r (p) | |
| Clinical Characteristics | |||
| Age | -0.40 (0.031)* | -0.41 (0.027)* | -0.39 (0.039)* |
| Duration | -0.29 (0.123) | -0.27 (0.152) | -0.27 (0.165) |
| Education | -0.08 (0.698) | -0.06 (0.767) | -0.11 (0.556) |
| 7T MRI Metrics | |||
| CA1-SP | 0.56 (0.005)* | 0.55 (0.005)* | 0.63 (0.001)* |
| CA1-SRLM | 0.06 (0.779) | 0.01 (0.966) | -0.084 (0.683) |
| DG | 0.02 (0.913) | 0.02 (0.905) | 0.03 (0.866) |
| Total Hippocampus | 0.27 (0.155) | 0.35 (0.066) | 0.29 (0.125) |
| z (p) | z (p) | z (p) | |
| Between correlation differences | |||
| CA1-SP vs CA1-SRLM | 1.9 (0.06) | 2.02 (0.04)* | 2.71 (0.007)* |
| CA1-SP vs DG | 2.07 (0.04)* | 2.05 (0.04)* | 2.39 (0.02)* |
| CA1-SP vs Total Hippocampus | 1.19 (0.23) | 0.90 (0.37) | 1.48 (0.14) |
Abbreviations: r: Pearson's correlation coefficient, z: Fisher r-to-z transformation, CA1-SP = CA1 stratum pyramidale layer, CA1-SRLM = CA1 stratum radiatum lacunosum moleculare, DG/CA3 = dentate gyrus and CA3 layer.
Bold indicates significance of p < 0.05