Table 2.

Distribution of the sodium level, difference, and correction time of adults admitted to ICU with hypernatremia at admission and hospital-acquired

Variable	Admission Hypernatremia, n=122; Median (IQR)			Hospital-Acquired Hypernatremia, n=327; Median (IQR)
	≤0.5 mmol/L per h	>0.5 mmol/L per h	P Value	≤0.5 mmol/L per h	>0.5 mmol/L per h	P Value
Total, n (%)	90 (74)	32 (26)		225 (69)	102 (31)
Serum sodium, mmol/L
at peak	162.0 (159.0–168.0)	166.0 (158.5–169.5)	0.4	157.0 (156.0–160.0)	159.0 (157.0–164.0)	<0.001
at 24 h	156.0 (153.0–160.0)	152.0 (145.5–157.0)	0.1	153.0 (150.0–156.0)	146.0 (143.0–152.0)	<0.001
after correction or last available	144.0 (143.0–145.0)	144.0 (141.0–145.0)	0.9	145.0 (143.0–149.0)	144.0 (142.0–145.0)	0.02
Serum sodium difference, mmol/L
at 24 h	7.5 (4.0–10.0)	13.0 (11.0–15.0)	<0.001	5.0 (3.0–7.0)	13.0 (8.0–19.0)	<0.001
at correction or last available	18.0 (14.0–24.0)	25.0 (13.0–31.5)	0.1	13.0 (10.0–15.0)	16.0 (13.0–21.0)	<0.001
Serum sodium time difference, h
at 24 h	19.4 (16.0–21.8)	18.0 (15.0–20.5)	0.2	18.2 (11.9–21.9)	14.7 (9.2–18.9)	<0.001
at correction or last available	69.2 (45.3–89.4)	24.0 (16.2–41.1)	<0.001	56.7 (34.1–88.8)	14.2 (6.7–23.4)	<0.001
Rate of sodium correction, mmol/L per h
at 0–24 h	0.4 (0.2–0.6)	0.7 (0.6–1.0)	<0.001	0.3 (0.2–0.4)	0.9 (0.6–1.6)	<0.001
Peak to normal level or last available	0.3 (0.2–0.4)	0.7 (0.6–1.4)	<0.001	0.2 (0.1–0.3)	0.9 (0.6–1.6)	<0.001

ICU, intensive care unit; IQR, interquartile range.