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Mean plasma concentration of tirabrutinib on Cycle 1, Day 1 (A) and on Cycle 1, Day 28 (B) in the fasting state (once or twice a day for 28 d) (Cohorts 1, 2, 3 and 4, Cycle 1, Day 1). The error bars indicate standard deviation (SD). BID, twice daily; QD, once daily
