Figure 7.

Raddeanin A (RA) inhibited tumor growth and induced apoptosis in an orthotopic osteosarcoma mouse model. 143B was injected into the medullary cavity of the tibia of each mouse. A, Macroscopic appearance of primary osteosarcoma tumors in the tibia and B, tumor weight quantification in BALB/c nude mice after treatment with RA or vehicle. C, TUNEL assay of tumor samples from legs in different treatment groups. D, Expression of phospho‐JNK, JNK, phospho‐c‐Jun, c‐Jun, phospho‐STAT3^S727, and STAT3 was analyzed in tumor tissues by western blotting. **P < 0.01 significantly different compared with vehicle control. STAT3, signal transducer and activator of transcription 3