Figure 3.

A, Immunohistochemistry images show reduced expression of estrogen receptor α (ERα) when Y‐box binding protein‐1 (YBX1) is overexpressed in mammary tumors induced by doxycycline in an experimental therapeutic model (Tet mock vs Tet YBX1). B, Overexpression of YBX1 in ERα‐positive breast cancer cells also induces resistance to endocrine therapy by tamoxifen in a xenograft experimental Tet YBX1 model compared with its Tet mock control. C, YBX1 expression is inversely correlated with ERα expression in human breast cancer. Heat map analysis of YBX1, ERα, and Ki67 in mammary tumors of breast cancer patients. D, Venn diagram showing the overlap of 322 genes between the top 500 genes that are positively correlated with YBX1 and the top 500 genes that are negatively correlated with estrogen receptor 1 (ESR1). Several representative genes are presented. E, Venn diagram showing the overlap of 352 genes between the top 500 genes that are positively correlated with ESR1 and the top 500 genes that are negatively correlated with YBX1. Several representative genes are presented