Figure 1.

Cinobufagin inhibits tumor growth and tumor angiogenesis in orthotopically transplanted colorectal carcinoma. A, Sizes of orthotopically transplanted colorectal carcinoma. B, Body weight of mice (n = 6). C, Tumor weight of control, cinobufagin (2 mg/kg and 4 mg/kg) and cisplatin treatment groups (n = 6). D, Tumor volume of control, cinobufagin and cisplatin treatment groups (n = 6). E, Representative images of immunohistochemical staining for CD31 (100×). a, control group; b, 2 mg/kg cinobufagin group; c, 4 mg/kg cinobufagin group; d, 0.5 mg/kg cisplatin group. F, Vascular area in xenotransplanted tumor tissues. Vascular endothelial cells were stained with CD31. ^# P < .05; *P < .01 compared to control group