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Sensitivity of NLDH120 mutants to soluble CD4 and mAbs. The neutralization sensitivity of the NLDH120 and mutants was determined with the same Magi assay that has been described in the Fig. 2 legend. The viruses were used to infect Magi cells in the presence of (A) soluble CD4, (B) IgGb12, (C) 17b, and (D) 2G12 and 2F5. IgGb12, 2G12, and 2F5 are mAbs that neutralize a broad spectrum of HIV-1 primary isolates.
