Table 2.
Meta-analyses of GNB3 825C>T, SCL6A4 5HTTLPR, and CCK-1R 779T>C polymorphisms and FD susceptibility.
| Group | Studies (n) | Case-control (n) | Additive model | |||
|---|---|---|---|---|---|---|
| GNB3 825C>T | OR (95% CI) | P value | I 2 (%) | P value | ||
| Overall | 13 | 1390/3058 | 1.15 (0.99-1.34) | 0.07 | 52.9 | 0.01 |
| Not deviate HWE | 11 | 1223/2677 | 1.16 (1.04-1.29) | 0.05 | 47.3 | 0.04 |
| EPS | 8 | 308/1787 | 1.34 (1.10-1.63) | 0.003 | 46.6 | 0.07 |
| HWE+ | 6 | 276/1594 | 1.44 (1.17-1.77) | 0.001 | 46.8 | 0.09 |
| PDS | 8 | 328/1787 | 1.19 (0.99-1.43) | 0.07 | 49.3 | 0.06 |
| Not deviate HWE | 6 | 261/1594 | 1.29 (1.03-1.62) | 0.03 | 36.3 | 0.17 |
| SCL6A4 5HTTLPR | OR (95% CI) | P value | I 2 (%) | P value | ||
| Overall | 4 | 326/1285 | 0.92 (0.75-1.12) | 0.40 | 57.0 | 0.07 |
| EPS | 3 | 106/949 | 0.73 (0.52-1.04) | 0.08 | 25.2 | 0.26 |
| PDS | 3 | 121/949 | 0.75 (0.54-1.04) | 0.08 | 57.2 | 0.10 |
| CCK-1R 779T>C | OR (95% CI) | P value | I 2 (%) | P value | ||
| Overall | 4 | 521/677 | 0.86 (0.72-1.03) | 0.09 | 40.9 | 0.17 |