Table 5.
Multivariate Cox regression analysis for overall survival, disease-free survival, and cancer-specific survival in patients with LSCC.
| OS | DFS | CSS | ||||
|---|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
| UA | ||||||
| UA > 0.315 | 1 | 1 | 1 | |||
| UA ≤ 0.315 | 1.458 (1.095-1.942) | 0.010 | 1.504 (1.131-2.001) | 0.005 | 1.494 (1.109-2.012) | 0.008 |
| UA/Cr ratio | ||||||
| UA/Cr ratio > 3.98 | 1 | 1 | 1 | |||
| UA/Cr ratio ≤ 3.98 | 1.337 (1.004-1.780) | 0.047 | 1.376 (1.030-1.839) | 0.031 | 1.420 (1.049-1.923) | 0.023 |
| TNM stage | ||||||
| I-II (n = 497) | 1 | 1 | 1 | |||
| III-IV (n = 317) | 2.732 (2.041-3.658) | <0.001 | 2.871 (2.145-3.842) | <0.001 | 3.131 (2.301-4.260) | <0.001 |
| T stage | ||||||
| T1-2 (n = 523) | 1 | 1 | 1 | |||
| T3-4 (n = 291) | 2.404 (1.804-3.202) | <0.001 | 2.524 (1.896-3.361) | <0.001 | 2.738 (2.028-3.697) | <0.001 |
| N stage | ||||||
| N0 (n = 722) | ||||||
| N1 (n = 31) | 1 | 1 | 1 | |||
| N2-3 (n = 61) | 3.196 (2.172-4.702) | <0.001 | 3.136 (2.253-4.882) | <0.001 | 3.372 (2.273-5.004) | <0.001 |
| Tumour subsite | ||||||
| Glottic and subglottic (n = 635) | 1 | 1 | 1 | |||
| Supraglottic (n = 179) | 2.205 (1.641-2.963) | <0.001 | 2.179 (1.621-2.927) | <0.001 | 2.332 (1.737-3.132) | <0.001 |
| Operation therapy | ||||||
| Partial laryngectomy (n = 488) | 1 | 1 | 1 | |||
| Total laryngectomy (n = 326) | 2.371 (1.794-3.135) | <0.001 | 2.508 (1.897-3.316) | <0.001 | 2.368 (1.791-3.130) | <0.001 |
| Tumour size | ||||||
| ≤2 cm (n = 511) | 1 | 1 | 1 | |||
| >2 cm (n = 303) | 2.640 (1.981-3.517) | <0.001 | 2.624 (1.969-3.497) | <0.001 | 2.724 (2.045-3.627) | <0.001 |
| Body mass index | ||||||
| <22.94 (413) | 1 | 1 | 1 | |||
| ≥22.94 (401) | 0.845 (0.631-1.132) | 0.259 | 0.842 (0.629-1.129) | 0.250 | 0.854 (0.637-1.144) | 0.289 |
| Age | ||||||
| <60 (n = 399) | 1 | 1 | 1 | |||
| ≥60 (n = 415) | 1.674 (1.241-2.259) | 0.001 | 1.585 (1.175-2.139) | 0.003 | 1.577 (1.157-2.149) | 0.004 |
| Hypertension | ||||||
| No (n = 585) | 1 | 1 | 1 | |||
| Yes (n = 229) | 1.142 (0.839-1.554) | 0.397 | 1.137 (0.836-1.548) | 0.414 | 1.193 (0.877-1.624) | 0.262 |
| Smoking history | ||||||
| No (n = 244) | 1 | 1 | 1 | |||
| Yes (n = 570) | 1.075 (0.752-1.536) | 0.692 | 1.082 (0.757-1.545) | 0.666 | 1.095 (0.766-1.567) | 0.618 |
| Drinking history | ||||||
| No (n = 505) | 1 | 1 | 1 | |||
| Yes (n = 309) | 1.132 (0.816-1.570) | 0.459 | 1.129 (0.814-1.566) | 0.467 | 1.162 (0.837-1.614) | 0.369 |
UA: uric acid; UA/Cr ratio: uric acid/creatinine ratio.