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. 2019 Apr 16;2019:1602892. doi: 10.1155/2019/1602892

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Copyright © 2019 Ruonan Zhai et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of AG and NG on renal histopathology and podocyte foot process effacement in diabetic rats. Representative hematoxylin and eosin (H&E, kidney histology (×400)) staining (a) and periodic acid-Schiff (PAS, kidney histology (×400)) staining (c) of kidney sections. Representative ultrastructure photos of glomerular podocytes taken by transmission electron microscopy (TEM) (×13500) (e). Semiquantitative analysis of mesangial expansion (b), mesangial area (d), and podocyte foot process density (f). FP: foot process; GBM: glomerular basement membrane; control: normal control rats; DN: STZ-induced diabetic rats; losartan: DN rats treated with losartan; AG: DN rats treated with Astragalus membranaceus; NG: DN rats treated with Panax notoginseng; AG+NG: DN rats treated with Astragalus membranaceus plus Panax notoginseng. Results were expressed as the mean ± SD. ^#P < 0.05 vs. control group, ^∗P < 0.05 vs. DN group, ^▲P < 0.05 vs. AG group, ^▼P < 0.05 vs. NG group.