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. 2019 Apr 22;2019:7940808. doi: 10.1155/2019/7940808

Figure 4.

Figure 4

ICA protected PC12 cells against AGE-induced apoptosis via the caspase-9/3 pathway. (a) PC12 cells were subjected to AGEs with or without ICA extract for 48 h. Mitochondrial depolarization was investigated by the JC-1 staining assay. The cells with depolarized mitochondria were identified by green fluorescence. Scale bar = 50 μm. (b) The cells were treated as in (a). The protein levels of caspase-3, PRAR, cleaved caspase-9, cleaved caspase-3, and cleaved PARP were examined by western blot. Data were presented as mean ± S.D. from independent experiments performed in triplicate. ###P < 0.001 relative to the control group; ∗P < 0.05 and ∗∗∗P < 0.001 relative to the model group.