TABLE III:

Identified Metabolites Differentiating Carnitine-treated 1-year Survivors from Non-survivors

	HMDB ID	Adduct (observed)	m/z (observed)	RT (min)	FDR-adjusted p value
Endogenous
N-Acetyl-L-phenylalanine	0000512	M+H	163.0355	3.37	0.0000
Adipoyl-L-carnitine	0028747	M+H	290.1436	2.48	0.0001
Fibrinopeptide A	C0952*	M+H	768.8494	9.12	0.0005
N-(3-acetamidopropyl)pyrrolidin-2-one	0061384		185.128028	3.8417	0.0008
N,N-dimethylguanosine	0004824	M+H	312.1302	3.56	0.0078
Phenylalanyl-tyrosine	0029007	M+H	329.153524	21.445	0.0105
Glucosamine	0001514	M+H	180.0875	3.560	0.0171
isoleucyl-proline / leucyl proline	0028908/0011175		229.154547	1.3083	0.0171
Allysine	0001263	M+Na	168.063352	1.7559	0.0187
N-Methyl-phenylalanine	0029224	M+H	142.9403	0.89	0.0218
Methoxytryptophol	0001896	M+H	192.104478	5.0838	0.0254
Histamine	0000870	M+Na	134.0687	3.165	0.0376
Pantetheine	0003426	M+H	279.1389	7.931	0.0475
Exogenous/drug-related
Pirbuterol	0015407	M+H	241.1543	1.49	0.0218

HMDB ID: human metabolomics database entry number (http://www.hmdb.ca/).

^*KEGG ID, no HMDB ID available.

All features were identified either by MS/MS spectral match with NIST 2017 MS/MS library or by accurate mass and retention time match with authentic standard in local metabolite library.