Figure 4.

Asymptomatic elderly individuals with high amyloid burden exhibit greater longitudinal tissue fractional anisotropy decline in the right uncinate fasciculus. Brain slice depicts corresponding reconstructed white matter fiber using TRACULA. The spaghetti plot on the left illustrates that participants that possessed significant Aβ burden in the brain that is, Aβ +ve (red) showed a greater longitudinal reduction in the RUNC FAt over time compared to Aβ −ve participants (blue). The scatterplot on the right illustrates that the spatial Aβ*Time effect (beta values) was greater in the temporal than orbitofrontal RUNC. Abbreviations: TRACULA, TRActs Constrained by UnderLying Anatomy; FAt, tissue fractional anisotropy; Aβ, amyloid beta; RUNC, right uncinate fasciculus