. 2019 Apr 21;2019:5026939. doi: 10.1155/2019/5026939

Table 3.

Correlation between COX-2 immunostaining and clinicopathological features of UCB.

Parameter		COX-2 immunostaining		p value
Parameter		Low	High	p value
Sex	Male	85	17	0.793^∗
Sex	Female	17	4	0.793^∗

Age	<60 years	41	6	0.320^∗
Age	≥60 years	61	15	0.320^∗

Grade	Low grade	30	1	0.013^∗
Grade	High grade	72	20	0.013^∗

Muscle invasion	Negative	40	2	0.017^#
	Positive	58	19
	Indeterminate	4	0

Pathological stage (pT)	pT1	44	2	0.003^#
	pT2	58	19
	pT3
	pT4

Nodal metastasis	Negative	85	13	0.08^∗
Nodal metastasis	Positive	17	8	0.08^∗

Distant metastasis	Negative	100	10	0.031^∗
Distant metastasis	Positive	2	11	0.031^∗

Lymphovascular invasion	Negative	97	4	0.008^∗
Lymphovascular invasion	Positive	5	17	0.008^∗

Anatomical stage	I	41	2	0.015^#
	II	61	19
	III
	IV

Local disease recurrence	Negative	69	14	0.931^∗
Local disease recurrence	Positive	33	7	0.931^∗

Survival	Alive	71	16	0.548^∗
Survival	Dead	31	5	0.548^∗

^#Kruskal-Wallis test; ^∗Mann-Whitney U test; T1: tumor invades subepithelial connective tissue; T2: tumor invades muscularis propria; T3: tumor invades perivesical tissue; T4: tumor invades any of the following: prostatic stroma, seminal vesicles, uterus, vagina, pelvic wall, or abdominal wall; stage I: T1, N0, and M0; stage II: T2, N0, and M0; stage III: T3 or T4a, N0, and M0; stage IV: any T and N1-3 or M1.