Table 1.
Transcription factor complexes and their control of interferon-stimulated genes
| ISGF3 | U-ISGF3 | GAS | |
|---|---|---|---|
| MX1/2 | IRF9 | MX1/2 | IFITM1 |
| IFITM1 | IRF4 | IFITM1 | STAT4 |
| PLSCR1 | cGAS | PLSCR1 | IRF1 |
| OAS1/2/3 | STAT1 | OAS1/2/3 | IRF8 |
| SOCS | STAT2 | IRF7 | IDO |
| USP18 | NOS2 | STAT1 | NOS2 |
| ISG15 | IFI27 | PDGFRA | |
| IRF3 | IFI44 | KRT14 | |
| IRF7 | IRF2 | ||
ISGF3 (interferon-stimulated gene factor 3), consists of phosphorylated STAT1 and STAT2 dimers bound to IRF9; U-ISGF3 (unphosphorylated interferon-stimulated gene factor 3), consists of a dimer of unphosphorylated STAT proteins bound to IRF9; GAS (gamma activated sequence), consists of phosphorylated STAT1 dimers