Fig. 1.

Schematic overview of the SCRABBLE algorithm. The objective function is shown on the top. It has three terms. The first term represents the difference between the raw scRNA-seq data matrix and its projection of the optimizing matrix. The projection of the optimizing matrix has the same profile of zeros as that of the raw scRNA-seq data. The second term is the rank of the optimizing matrix. The third term represents the difference between the bulk RNA-seq data and the aggregated scRNA-seq data across cells. Here, the bulk data represent the composite mix of all cell types without sorting them into individual types