Table 2.

Cell responses to cerebral ischemia within the neurovascular unit.

	Cell	Ischemic core	Ischemic periphery	References
With treatment	Neuron	Loss	Axonal outgrowth	Li et al.60 Ishizaka et al.23 Kanazawa et al.20
	Endothelial cell	Angiogenesis18–24,52,99 (border area)	Angiogenesis23,57,146,147	Abumiya et al.19 Zhang et al.52 Marti et al.21 Hill et al.22 Taguchi et al.147 Li et al.18,99 Wang et al.146 Ishizaka et al.201323 Chen et al.57 Jiang et al.24 Kanazawa et al.20
	Pericyte	Proliferation and coverage of capillaries very increased	Proliferation and coverage of capillaries increased	Fernández-Klett et al.62 Hall et al.105 Kanazawa et al.20
Without treatment	Microglia	Very increased density	Increased density	Mabuchi et al.131 Li et al.18 Kanazawa et al.132 Jiang et al.24 Kanazawa et al.20 Zarruk et al.133
	Astrocyte	No change	Proliferation/gliosis	Hill et al.22 Li et al.60 Kanazawa et al.61 Li et al.18 Fernández-Klett et al.62 Jiang et al.24 Kanazawa et al.20