Table 2.
Odds ratio estimates for coding variants in MC1R, MITF, and BRCA2 with five or more allele counts among cases and controls.
| Gene | Variant | Allele frequency | Case | Control | Odds ratio | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SKCM | NDAR | Carrier | Non-carrier | Carrier | Non-carrier | Crude | Adjusted | Reported | Meta analysis* | |||
| MC1R | rs1805008 | 11.02% | 7.55% | 68 | 254 | 511 | 3024 | 1.58 (1.19–2.10) | 1.49 (1.11–1.99) | 1.43 (1.20–1.70) | 1.45 (1.24–1.68) | |
| rs1805007 | 10.90% | 7.70% | 66 | 255 | 530 | 3069 | 1.50 (1.13–1.99) | 1.56 (1.16–2.10) | 1.78 (1.45–2.20) | 1.70 (1.44–2.02) | ||
| rs1805009 | 2.95% | 1.73% | 19 | 303 | 124 | 3482 | 1.76 (1.07–2.89) | 2.15 (1.30–3.57) | 1.77 (1.17–2.69) | [37] | 1.91 (1.39–2.64) | |
| rs1805006 | 2.17% | 0.80% | 14 | 308 | 58 | 3548 | 2.78 (1.53–5.04) | 3.00 (1.63–5.54) | 2.40 (1.50–3.84) | 2.61 (1.80–3.78) | ||
| rs11547464 | 0.93% | 0.61% | 6 | 316 | 43 | 3562 | 1.57 (0.66–3.72) | 1.36 (0.55–3.38) | 1.66 (1.01–2.75) | 1.58 (1.02–2.46) | ||
| BRCA2 | rs766173 | 5.28% | 3.22% | 34 | 288 | 227 | 3375 | 1.76 (1.20–2.57) | 1.81 (1.22–2.69) | na | na | |
| rs1799944 | 5.28% | 3.04% | 34 | 288 | 204 | 3298 | 1.91 (1.30–2.80) | 2.03 (1.36–3.02) | 1.84 (1.34–2.51) | [8] | 1.87 (1.47–2.38) | |
| MITF | rs149617956 | 0.78% | 0.19% | 5 | 317 | 14 | 3593 | 4.05 (1.45–11.31) | 4.48 (1.57–12.78) | 8.37 (2.58–23.80) | [7] | 6.01 (2.81–12.89) |
*
The OR in meta-analysis was calculated by combing the adjusted OR and reported OR from literature.