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. 2019 Apr 29;10:435. doi: 10.3389/fphar.2019.00435

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Copyright © 2019 Furini, Giuliani, Parlati, Govoni, Di Virgilio and Bortoluzzi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representation of IL-1β and IL-6 plasma levels in patients with serositis (SLE-S), without serositis (SLE-NS) compared to healthy control (HC). (A) Plasma IL-1β levels were not statistically significant between HC, SLE-S, and SLE-NS (SLE-NS vs. HC = 6.39 ± 1.13 vs. 5.42 ± 0.384, p = 0.45), (SLE-S vs. HC = 6.07 ± 0.38 vs. 5.42 ± 0.38, p = 0.246), (SLE-S vs. SLE-NS = 6.07 ± 0.38 vs. 6.39 ± 1.13, p = 0.80). Unpaired t-test. (B) Plasma IL-6 levels resulted significantly higher in SLE-S compared to both HC and SLE-NS: (SLE-NS vs. HC = 2.02 ± 0.37 vs. 1.58 ± 0.67, p = 0.54), (SLE-S vs. HC = 4.8 ± 0.97 vs. 1.58 ± 0.67, p = 0.037), (SLE-S vs. SLE-NS 4.8 ± 0.97 vs. 2.02 ± 0.37, p = 0.009). Unpaired t-test. Data are means ± SE. Only significant differences are shown. ^∗p < 0.05, ^∗∗p < 0.01.