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. Author manuscript; available in PMC: 2019 Jun 5.
Published in final edited form as: Structure. 2018 May 10;26(6):857–868.e4. doi: 10.1016/j.str.2018.04.005

Figure 1.

Figure 1

From Fibrin Oligomer to Fibrin Protofibril Based on Computational Crystallomics (A) Structure of short fibrin oligomer FO2/3 used as an elementary building block, which contains five fibrin monomers (Zhmurov et al., 2016). (B) Schematic of elongation procedure used to reconstruct longer oligomers FOm/n starting from short oligomers FO2/3 as described in the text (Results; see also STAR Methods and Figure S1). (C) Workflow involved in introducing the twist into the structure of fibrin oligomers and protofibril as described in the text (Results; see also STAR Methods). (D) Final stage of protofibril reconstruction, in which all steric clashes are removed and the αC chains are incorporated (Results; see also STAR Methods).