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A Proposed Model of PUB40-Mediated Degradation of BZR1 in Arabidopsis Roots.
In the absence of BR, BIN2 constitutively phosphorylates both BZR1 and PUB40 in roots. BIN2-induced phosphorylation increases PUB40 stability as well as the binding of PUB40 to BZR1. PUB40 primarily ubiquitinates BZR1, leading to 26S proteasomal degradation of BZR1 in roots. The thick arrow indicates prominent ubiquitination. P, phosphorylation. Ub, ubiquitination.
