Table 1.

Alterations of ADPr genes associated with human inherited pathologies.

gene	gene alteration	disease/disorder	references
transferases
PARP9	overexpression	B-aggressive lymphoma	[11,12]
		breast cancer	[13]
PARP14	overexpression	B-aggressive lymphoma	[11,14]
		sarcoma	[15]
		asthma	[16]
		hepatocellular carcinoma	[17]
PARP15	overexpression	B-aggressive lymphoma	[11]
readers/erasers
ALC1 (CHD1L)	overexpression	hepatocellular carcinoma	[18]
		breast cancer	[19]
		colorectal carcinoma	[20]
ARH1	missense mutations	lung, breast and colon cancers	[21]
ARH3	truncations/mutations	neurodegenerative diseases	[22,23]
GDAP2 (MacroD3)	point mutations	ataxia, progressive spasticity and dementia	[24]
MacroD1	overexpression	endometrial carcinoma	[25]
		gastric carcinoma	[26]
		colorectal carcinoma	[27,28]
		breast carcinoma	[29,30]
MacroD2	single-nucleotide polymorphisms	autism	[31–33]
	microdeletion Int 5	kabuki syndrome	[34,35]
	locus deletions	various cancers	[36,37]
	deletions, missense mutations	colorectal cancer	[38]
TARG1	premature stop codon	neurodegeneration	[39]