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. 2019 May 1;11:3779–3790. doi: 10.2147/CMAR.S185438

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© 2019 Yang et al. This work is published and licensed by Dove Medical Press Limited

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Effects of FOXM1 on the expressions of β-catenin target genes in CRC cells.

Notes: The protein and mRNA levels of β-catenin target genes, such as cyclin D1, TCF-4 and c-Myc, were measured using western blots and qRT-PCR analysis. (A–D) The mRNA expression of cyclin D1, TCF-4, and c-Myc was found to be increased significantly in FOXM1-overexpression DLD-1 cells compared to mock and control transfectants. *P<0.05, **P<0.01. (E–H) FOXM1 knocking down obviously downregulated the cyclin D1, TCF-4, and c-Myc mRNA expression levels in HCT116 cells after tranfection with si-FOXM1. **P<0.01, *P<0.05. All the results were measured at least three times.

Abbreviations: qRT-PCR, quantitative RT-PCR; si-control, control-siRNA; si-FOXM1, FOXM1 siRNA; TCF-4, T-cell factor-4; pFOXM1, pcDNA3.1-FOXM1.