Table 3.
Top five affected ingenuity canonical pathways enriched in CSF between NOD and CON macaques
| Pathway name | Total | Hits | P-value | FDR | Matching IDs |
|---|---|---|---|---|---|
| Fatty acid biosynthesis | 16 | 6 | 2.98e-06 | 1.01e-04 | HMDB00042 HMDB00691 HMDB00039 HMDB00220 HMDB00207 HMDB00827 |
| ABC transporters | 22 | 5 | 5.43e-05 | 1.36e-03 | HMDB00123 HMDB00167 HMDB00191 HMDB01414 HMDB00215 |
| Aminoacyl-tRNA biosynthesis | 20 | 4 | 1.63e-04 | 5.22e-03 | HMDB00162 HMDB00123 HMDB00167 HMDB00191 |
| Aspartate metabolism | 16 | 3 | 5.69e-04 | 9.67e-03 | HMDB00691 HMDB00056 HMDB00191 |
| Threonine degradation | 17 | 3 | 1.69e-04 | 1.46e-02 | HMDB00237 HMDB00123 HMDB00167 |
Abbreviations: CON, control; NOD, naturally occurring depressive; CSF, cerebrospinal fluid; FDR, false discovery rate.