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. 2019 Apr 29;13:134. doi: 10.3389/fncel.2019.00134

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Copyright © 2019 Batra, Corcoran, Zhang, Pal, K.P., Kulkarni, Löfstedt, Sowdhamini and Olsson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bioinformatics analysis for interaction of coffee furanone with Or22a and Or42b in Drosophila melanogaster. Amino acid residues in interaction within 5Å of coffee furanone as depicted by ligand interaction diagram for pairs (A) Or22a-coffee furanone; (B) Or42b-coffee furanone; (C) Multiple sequence alignment of olfactory receptors highlighting the extracellular loop-2 region. The conserved proline residue found in predicted binding pockets is highlighted by arrow on top. Motif YFP (residues 173-175) and PFI (residues 172-174) in Or22a and Or42b, respectively, are underlined. Green represents Ors expressed in OSNs strongly activated by coffee furanone in our electrophysiology studies; yellow represents Ors in weakly activated OSNs, and red represents Ors in OSNs that are not activated by coffee furanone. (D) Evolutionary conserved residues Tyr 173 (Y), Pro 175 (P) and Glu 190 (E) in extracellular loop-2 for Or22a-Or42b class are highlighted as orange in dockpose of Or22a with ligands coffee furanone (red), and ethyl butyrate (blue).