Figure 5. Invasiveness as ratio of complete population replacement vs. loss of gene drive construct per generation.

Each gene drive technique shows an asymptotic behaviour with the exception of the CRISPR/Cas-mediated gene drives, due to the formation of resistance alleles (labelled as w/Res). A comparable CRISPR/Cas-mediated gene drive without resistance allele formation (labelled as w/o Res) shows asymptotic behaviour as well. (A) GD techniques on a decimal scale. (B) GD Techniques on a logarithmic scale compared to the fitted curves for transgenes with fitness loss (power) and fitness gain (polynomial).