Table 2. Comparison of gene drive-specific characteristics.

		X-Shredder	Killer-Rescue	Medea	Two-locus UD	CRISPR/Cas
	Mode of action	Sex ratio/ Chromosomal disruption	Toxin/Antidote	Toxin/Antidote	Toxin/Antidote	Heterozygote to homozygote conversion
Depth of intervention	Class	Suppression	Replacement	Replacement	Replacement	Replacement
	Range	High	Low	High	Low	High
	Invasiveness	Moderate	Low	High	Moderate	Very high
Intensity of intervention		High	High	High	High	Low
Reliability	Resistance formation	Very unlikely	Possible	Possible	Unlikely	Likely
	Linkage Loss	Unknown	Unknown	Unlikely	Unlikely	Likely
Risk management	Reversibility	None, maybe CRISPR/Cas-based overwriting drive	Wild type release	2nd generation Medea drive	Wild type release	Overwriting drive