Table 2.
Candidate heart failure biomarkers based upon DNA-aptamer proteomic results from discarded clinical plasma specimens
| Protein (levels in relative fluorescent units) | HF N = 48 |
No HF N = 47 |
p | % Difference |
|---|---|---|---|---|
| Cystatin-C | 2272 (1896, 2963) | 1434 (1263, 1772) | 2.04 × 10−10 | 58 |
| Renin | 1238 (709, 1945) | 393 (289, 610) | 4.74 × 10−10 | 215 |
| Thrombospondin-2 | 21260 (13500, 32150) | 9094 (7242, 13680) | 9.60 × 10−9 | 134 |
| Insulin like growth factor binding protein-6 | 697 (516, 884) | 442 (406, 514) | 1.46 × 10−8 | 58 |
| Angiopoietin-2 | 593 (461, 791) | 393 (331, 468) | 3.51 × 10−7 | 51 |
| Interleukin-17 receptor C | 1729 (1331, 2329) | 1065 (882, 1389) | 4.24 × 10−7 | 62 |
| Kallikrein-11 | 1866 (1206, 2279) | 1073 (901, 1339) | 4.58 × 10−7 | 74 |
| Macrophage colony-stimulating factor-1 | 2166 (1663, 2733) | 1292 (1138, 1553) | 6.87 × 10−7 | 68 |
| Leukotriene A-4 hydrolase | 1763 (1165, 2344) | 955 (796, 1187) | 4.60 × 10−6 | 85 |
Values presented at median (25th, 75th percentile) relative fluorescence units. HF = heart failure. Percent difference calculated as the difference in median values between HF cases and controls (HF minus no HF)/no HF. P value from Wilcoxon rank-sum test using a Bonferroni-corrected p-value threshold of 4.42 × 10−5 = 0.05 / 1,129 proteins assayed. The % difference in median values was calculated as 100 x (median RFU in HF cases – median RFU in controls)/median RFU in controls.