Table 3A.
Adjusted HR for minor amputations and 95% CI for type 1 diabetes vs controls, time-updated mean HbA1c categories, albuminuria categories, and eGFR categories examined by Cox regression
| Amputation below ankle | HR (95% CI), p value | |||
| Diabetes duration 30years | Diabetes duration 40years | Diabetes duration 50years | Diabetes duration 60years | |
| Overall | ||||
| Controls (reference) | 1.00 | 1.00 | 1.00 | 1.00 |
| Group all type 1 diabetes with no prior amputation | 75.7 (52.6 to 109.0)* | 86.3 (60.2 to 123.8)* | 98.4 (67.3 to 143.9)* | 112.3 (73.7 to 171.0)* |
| Time-updated mean HbA1c categories | ||||
| ≤52 mmol/mol (≤6.9%) | 27.3 (16.7 to 44.7)* | 32.0 (19.7 to 52.0)* | 37.4 (22.8 to 61.5)* | 43.7 (25.9 to 74.0)* |
| 53–62 mmol/mol (7.0%–7.8%) | 45.0 (30.2 to 67.2)* | 52.7 (35.6 to 77.9)* | 61.6 (41.1 to 92.4)* | 72.0 (46.5 to 111.7)* |
| 63–72 mmol/mol (7.9%–8.7%) | 65.7 (44.6 to 96.7)* | 76.8 (52.5 to 112.2)* | 89.8 (60.5 to 133.2)* | 105.0 (68.3 to 161.5)* |
| 73–82 mmol/mol (8.8%–9.6%) | 123.4 (83.4 to 182.6)* | 144.4 (98.3 to 212.1)* | 168.9 (113.1 to 252.0)* | 197.5 (127.6 to 305.6)* |
| ≥83 mmol/mol (≥9.7%) | 299.7 (201.5 to 445.6)* | 350.5 (237.2 to 517.8)* | 409.9 (273.0 to 615.4)* | 479.4 (308.0 to 746.3)* |
| Time-updated albuminuria categories | ||||
| Normoalbuminuria | 48.6 (33.1 to 71.4)* | 50.4 (34.5 to 73.7)* | 52.4 (35.1 to 78.2)* | 54.3 (34.8 to 85.0)* |
| Microalbuminuria | 130.6 (87.5 to 195.1)* | 135.5 (91.7 to 200.2)* | 140.6 (93.6 to 211.2)* | 145.9 (93.3 to 228.1)* |
| Macroalbuminuria | 209.2 (139.4 to 314.1)* | 217.0 (146.2 to 322.0)* | 225.2 (149.5 to 339.4)* | 233.7 (149.2 to 366.2)* |
| CKD stage 5 | 623.7 (408.4 to 952.6)* | 646.8 (428.6 to 975.9)* | 671.5 (439.1 to 1026.8)* | 696.7 (439.2 to 1105.2)* |
| Time-updated eGFR categories | ||||
| CKD stage 1 (eGFR ≥90) | 45.9 (30.6 to 69.0)* | 47.2 (31.5 to 70.7)* | 48.5 (31.6 to 74.5)* | 49.8 (31.0 to 80.2)* |
| CKD stage 2 (eGFR 60–89) | 75.3 (51.2 to 110.8)* | 77.3 (52.9 to 113.2)* | 79.5 (53.1 to 118.9)* | 81.7 (52.1 to 128.0)* |
| CKD stage 3 (eGFR 30–59) | 160.5 (106.4 to 242.1)* | 164.9 (110.6 to 245.9)* | 169.5 (111.9 to 256.7)* | 174.2 (110.6 to 274.5)* |
| CKD stage 4 (eGFR 15–29) | 190.8 (111.7 to 325.9)* | 196.0 (115.7 to 332.2)* | 201.5 (117.4 to 345.7)* | 207.2 (117.0 to 366.8)* |
| CKD stage 5 (eGFR <15, dialysis or transplantation) | 623.1 (408.2 to 950.9)* | 640.1 (424.0 to 966.4)* | 658.0 (429.3 to 1008.5)* | 676.2 (424.5 to 1077.1)* |
All models are adjusted for time-updated age, sex, born in Sweden, maximum educational level, baseline comorbidities and time-updated diabetes duration centered at 30, 40, 50 and 60 years.
*Significant at p<0.0001.