Table 4B.

Adjusted HRs of major amputations for people with type 1 diabetes vs controls and 95% CIs for time-updated mean HbA1c categories and coexisting normoalbuminuria and eGFR >60 mL/min

Amputation above ankle	HR (95% CI), p value
	Diabetes duration 30years	Diabetes duration 40years	Diabetes duration 50years	Diabetes duration 60years
Time-updated mean HbA1c categories and albuminuria
Controls (reference)	1.00	1.00	1.00	1.00
≤52 mmol/mol (≤6.9%)—normoalbuminuria	5.6 (3.1 to 10.2)*	7.3 (4.1 to 13.2)*	9.5 (5.3 to 17.2)*	12.4 (6.7 to 22.8)*
53–62 mmol/mol (7.0%–7.8%)—normoalbuminuria	8.9 (6.0 to 13.1)*	11.6 (8.0 to 16.7)*	15.0 (10.3 to 21.9)*	19.5 (13.0 to 29.3)*
63–72 mmol/mol (7.9%–8.7%)—normoalbuminuria	11.1 (7.7 to 16.2)*	14.5 (10.1 to 20.7)*	18.8 (13.0 to 27.1)*	24.4 (16.3 to 36.5)*
73–82 mmol/mol (8.8%–9.6%)—normoalbuminuria	17.6 (11.3 to 27.4)*	22.9 (14.9 to 35.2)*	29.7 (19.1 to 46.1)*	38.6 (24.1 to 61.7)*
≥83 mmol/mol (≥9.7%)—normoalbuminuria	71.7 (46.6 to 110.3)*	93.2 (61.1 to 142.1)*	121.0 (78.3 to 186.9)*	157.2 (98.5 to 251.1)*
≤52 mmol/mol (≤6.9%)—not normoalbuminuria	17.1 (9.7 to 30.1)*	22.2 (12.9 to 38.4)*	28.9 (16.7 to 49.8)*	37.5 (21.4 to 65.8)*
53–62 mmol/mol (7.0%–7.8%)—not normoalbuminuria	25.9 (18.0 to 37.4)*	33.7 (23.9 to 47.4)*	43.7 (31.1 to 61.5)*	56.8 (39.3 to 82.2)*
63–72 mmol/mol (7.9%–8.7%)—not normoalbuminuria	41.2 (29.9 to 56.8)*	53.5 (39.7 to 72.0)*	69.5 (51.3 to 94.1)*	90.3 (64.3 to 126.7)*
73–82 mmol/mol (8.8%–9.6%)—not normoalbuminuria	55.0 (39.4 to 76.9)*	71.5 (52.1 to 98.1)*	92.8 (67.0 to 128.6)*	120.7 (84.0 to 173.3)*
≥83 mmol/mol (≥9.7%)—not normoalbuminuria	139.2 (99.4 to 195.0)*	180.9 (131.4 to 248.9)*	234.8 (168.7 to 326.7)*	305.2 (211.4 to 440.7)*
Time-updated mean HbA1c categories and eGFR
≤52 mmol/mol (≤6.9%)—eGFR ≥60	6.8 (3.9 to 11.7)*	8.6 (5.0 to 14.8)*	11.0 (6.4 to 19.0)*	14.1 (8.0 to 24.8)*
53–62 mmol/mol (7.0%–7.8%)—eGFR ≥60	10.3 (7.1 to14.8)*	13.1 (9.3 to 18.5)*	16.8 (11.8 to 23.9)*	21.4 (14.5 to 31.5)*
63–72 mmol/mol (7.9%–8.7%)—eGFR ≥60	16.0 (11.5 to 22.2)*	20.4 (15.0 to 27.9)*	26.1 (18.9 to 36.0)*	33.3 (23.2 to 47.8)*
73–82 mmol/mol (8.8%–9.6%)—eGFR ≥60	19.4 (13.1 to 28.7)*	24.8 (17.0 to 36.2)*	31.7 (21.5 to 46.7)*	40.4 (26.5 to 61.8)*
≥83 mmol/mol (≥9.7%)—eGFR ≥60	67.3 (45.3 to 99.8)*	85.9 (58.4 to 126.3)*	109.6 (73.4 to 163.8)*	140.0 (90.2 to 217.2)*
≤52 mmol/mol (≤6.9%)—eGFR <60	17.2 (9.4 to 31.2)*	21.9 (12.3 to 39.1)*	28.0 (15.7 to 49.8)*	35.7 (19.7 to 64.6)*
53–62 mmol/mol (7.0%–7.8%)—eGFR <60	24.6 (16.5 to 36.7)*	31.4 (21.6 to 45.7)*	40.1 (27.6 to 58.3)*	51.2 (34.5 to 76.2)*
63–72 mmol/mol (7.9%–8.7%)—eGFR <60	39.4 (27.6 to 56.4)*	50.4 (36.1 to 70.2)*	64.3 (45.9 to 90.0)*	82.1 (56.8 to 118.5)*
73–82 mmol/mol (8.8%–9.6%)—eGFR <60	69.0 (47.7 to 99.9)*	88.1 (62.3 to 124.8)*	112.5 (79.1 to 160.0)*	143.6 (97.9 to 210.7)*
≥83 mmol/mol (≥9.7%)—eGFR <60	166.2 (114.5 to 241.4)*	212.3 (149.3 to 301.9)*	271.0 (189.4 to 387.6)*	346.0 (234.3 to 510.8)*

Adjusted for time-updated age, sex, born in Sweden, maximum educational level, baseline comorbidities and time-updated diabetes duration centered at 30, 40, 50 and 60 years.

*Significant at p<0.0001.

eGFR, estimated glomerular filtration rate; HbA1c, hemoglobin A1c.