. 2019 Mar 21;7(1):e000627. doi: 10.1136/bmjdrc-2018-000627

Table 1.

Variables and criteria used to assess eligibility of patients in the DISCOVER study for inclusion in CANVAS, DECLARE-TIMI 58, EMPA-REG OUTCOME, and VERTIS-CV

Criterion	CANVAS	DECLARE-TIMI 58	EMPA-REG OUTCOME	VERTIS-CV
All patients
HbA_1c, %	7.0–10.5	6.5–12.0	7.0–10.0	7.0–10.5
CKD history	Patients were excluded if: eGFR was reported and <30 mL/min/1.73 m². Or if CKD was marked as present by the investigator.	Patients were excluded if: eGFR was reported and <60 mL/min/1.73 m². Or if CKD was marked as present by the investigator.	Patients were excluded if: eGFR was reported and <30 mL/min/1.73 m². Or if CKD was marked as present by the investigator.	No exclusion criterion.
BMI, kg/m²	No criterion			≥18.0
Patients with CV risk factors but no established CVD
Age, years	≥50	>55 (men), >60 (women)	NA.*	NA.*
CV risk factors	At least two of the following risk factors: Dyslipidemia. LDL-C ≥154 mg/dL. Or HDL-C ≤39 mg/dL. Or use of lipid-lowering therapy. Or hyperlipidemia marked as present by investigator. Duration of diabetes ≥10 years. Current smoker.	At least one of the following risk factors: Dyslipidemia. LDL-C >130 mg/dL. Or use of lipid-lowering therapy. Or hyperlipidemia marked as present by the investigator. Hypertension SBP >140 mm Hg. Or DBP >90 mm Hg. Or use of BP-lowering therapy. Or hypertension marked as present by the investigator. Current smoker.	NA.*	NA.*
Patients with established CVD
Age, years	≥30	≥40	≥18	≥40
CV history	History of at least one of the following: Angina CABG. CAD. Ischemic stroke. HF. MI. PCI.	History of at least one of the following: CABG CAD. Carotid stenting. Endarterectomy. Ischemic stroke. Lower extremity amputation. MI. PAD. PCI.	History of at least one of the following: Angina. CABG. CAD. Ischemic or hemorrhagic stroke. Lower extremity amputation. MI. PAD. PCI.	History of at least one of the following: Angina. CABG. CAD. Ischemic stroke. MI. PAD. PCI.

*No patients without established CVD in EMPA-REG OUTCOME and VERTIS-CV.

BMI, body mass index;BP, blood pressure;CABG, coronary artery bypass graft;CAD, coronary artery disease;CKD, chronic kidney disease;CV, cardiovascular;CVD, cardiovascular disease;DBP, diastolic blood pressure;eGFR, estimated glomerular filtration rate;HbA_1c, glycated hemoglobin;HDL-C, high-density lipoprotein cholesterol;HF, heart failure;LDL-C, low-density lipoprotein cholesterol;MI, myocardial infarction;NA, not applicable;PAD, peripheral artery disease;PCI, percutaneous coronary intervention;SBP, systolic blood pressure.