Table 2.

Study procedures during admission

	Day 0	Day 1	Day 2	Day 3	Day 4
Vital signs	Preinoculation then four hourly	Four hourly	Four hourly	Four hourly	Four hourly
Review of adverse events	Four hourly	Four hourly	Four hourly	Four hourly	Four hourly
Medical review	×2	×2	×2	×2	×2
Pregnancy test (females only)	+
Review eligibility	+
Inoculation	+
Throat swab (culture)	+		+	+	+
Throat swab (microbiome)	+			+
Nasal wash				+
Nasosorption test	+			+
Saliva sample	+			+
Environmental samples		+	+	+	+
Safety bloods (mL)	8			8
Immunological blood tests (mL)	70