Table 1.

Sample size calculations: sample size fixed at 3000 and α for the first co-primary outcome (mortality) fixed at 0.04 and the second co-primary outcome calculated at 0.012

Power calculation
	Control event rate
Sample size fixed at 3000 and α for the first co-primary outcome (mortality) fixed at 0.04
HR	12.5%	13.0%	13.5 %
0.73	0.785	0.801	0.816
0.70	0.873	0.886	0.897
0.65	0.96	0.966	0.971
Sample size fixed at 3000 and α for the second co-primary outcome* at 0.012 (calculated)
HR	27.5%	30%	32.5%
0.75	0.916	0.941	0.958
0.70	0.988	0.993	0.996
0.65	0.9992	0.9997	0.9999

*Composite outcome of major perioperative complications (ie, mortality, non-fatal myocardial infarction, pulmonary embolism, pneumonia, sepsis, stroke, and life-threatening and major bleeding).