Table 3.

Rates and RRs for falls and fractures estimated over the study period in OAB cohort 2 and in the non-OAB cohort, according to baseline anticholinergic burden; Truven MarketScan databases 2007–2015

	OAB cohort 2	Non-OAB cohort	OAB versus non-OAB RRs
	n=43 483	n=86 966	n=130 449
Fall and fracture rates (95% CI) per 100 person-years
Overall, crude rate	4.8 (4.7 to 5.0)	3.5 (3.5, to 3.6)	1.4 (1.3 to 1.5)
By baseline anticholinergic burden level*
No burden (0)	3.1 (2.9 to 3.3)	2.7 (2.6 to 2.8)	1.2 (1.1 to 1.3)
Low (1–89)	4.3 (4.0 to 4.6)	3.8 (3.6 to 4.0)	1.1 (1.0 to 1.2)
Medium (90–499)	5.5 (5.2 to 5.8)	5.1 (4.9 to 5.4)	1.1 (1.0 to 1.2)
High (500+)	6.9 (6.6 to 7.3)	8.1 (7.4 to 8.8)	0.9 (0.8 to 0.9)
RRs, by anticholinergic burden level
Any burden versus no burden	1.8 (1.7 to 1.9)	1.8 (1.7 to 1.9)
Low burden versus no burden	1.4 (1.3 to 1.5)	1.4 (1.3 to 1.5)
Medium burden versus no burden	1.7 (1.6 to 1.9)	1.9 (1.8 to 2.0)
High burden versus no burden	2.2 (2.0 to 2.4)	3.0 (2.7 to 3.3)

*Baseline anticholinergic burden assessed over the 12-vmonth pre-index period.

OAB, overactive bladder; RR, rate ratio.