Table 2.
Difference in cumulative percentage revision of knee constructs compared with a contemporary benchmark at 5 years postprimary in women for knee replacements with ≥250 procedures remaining at risk
| Knee brand, bearing and constraint | Number at risk |
Cumulative failure (%) |
Difference in failure (%) |
95% CI | Equivalence status |
P value |
| (TKR) MRK cemented, unconstrained fixed | 2570 | 1.35 | (Reference) | |||
| (TKR) AGC cemented, posterior-stabilised fixed | 264 | 2.65 | 1.31 | (−0.54 to 3.16) | Non-inferiority not shown | 0.083 |
| (TKR) AGC cemented, unconstrained fixed | 23 829 | 1.85 | 0.50 | (0.13 to 0.88) | Non-inferiority not shown | 0.004 |
| (TKR) AGC hybrid, unconstrained fixed | 431 | 3.11 | 1.76 | (0.17 to 3.35) | Non-inferiority not shown | 0.015 |
| (TKR) AGC uncemented, unconstrained fixed | 502 | 5.34 | 4.00 | (2.10 to 5.89) | Inferior by ≥100% | <0.001 |
| (TKR) Advance MP cemented, unconstrained fixed | 2264 | 2.46 | 1.11 | (0.48 to 1.75) | Inferior by ≥20% | <0.001 |
| (TKR) Advance MP Stature cemented, unconstrained fixed | 378 | 2.93 | 1.58 | (0.31 to 2.86) | Inferior by ≥20% | 0.007 |
| (TKR) Advance PS cemented, posterior-stabilised fixed | 354 | 2.97 | 1.62 | (0.09 to 3.15) | Non-inferiority not shown | 0.019 |
| (TKR) Columbus cemented, unconstrained fixed | 1595 | 2.53 | 1.19 | (0.54 to 1.83) | Inferior by ≥20% | <0.001 |
| (TKR) E-Motion Bicondylar Knee uncemented, unconstrained mobile | 544 | 3.22 | 1.87 | (0.57 to 3.17) | Inferior by ≥20% | 0.002 |
| (TKR) FS cemented, unconstrained fixed | 397 | 2.34 | 0.99 | (−0.48 to 2.47) | Non-inferiority not shown | 0.093 |
| (TKR) Genesis 2 cemented, posterior-stabilised fixed | 2848 | 2.15 | 0.80 | (0.29 to 1.32) | Inferior by≥20% | 0.001 |
| (TKR) Genesis 2 cemented, unconstrained fixed | 9021 | 1.44 | 0.10 | (−0.29 to 0.49) | Non-inferiority not shown | 0.311 |
| (TKR) Genesis 2 cemented, unconstrained mobile | 464 | 1.48 | 0.14 | (−0.94 to 1.22) | Non-inferiority not shown | 0.401 |
| (TKR) Genesis 2 Oxinium cemented, posterior-stabilised fixed | 620 | 3.49 | 2.14 | (1.00 to 3.29) | Inferior by ≥20% | <0.001 |
| (TKR) Genesis 2 Oxinium cemented, unconstrained fixed | 1485 | 2.75 | 1.41 | (0.63 to 2.19) | Inferior by ≥20% | <0.001 |
| (TKR) Insall-Burstein 2 cemented, posterior-stabilised fixed | 1177 | 2.63 | 1.28 | (0.33 to 2.23) | Inferior by ≥20% | 0.004 |
| (TKR) Journey Oxinium cemented, posterior-stabilised fixed | 283 | 7.30 | 5.96 | (3.45 to 8.47) | Inferior by ≥100% | <0.001 |
| (TKR) Kinemax cemented, unconstrained fixed | 5369 | 2.41 | 1.07 | (0.54 to 1.59) | Inferior by ≥20% | <0.001 |
| (TKR) LCS cemented, unconstrained mobile | 340 | 1.85 | 0.51 | (−0.90 to 1.91) | Non-inferiority not shown | 0.239 |
| (TKR) LCS Complete cemented, unconstrained mobile | 3759 | 2.62 | 1.28 | (0.72 to 1.84) | Inferior by ≥20% | <0.001 |
| (TKR) LCS Complete uncemented, unconstrained mobile | 4205 | 2.61 | 1.26 | (0.73 to 1.80) | Inferior by ≥20% | <0.001 |
| (TKR) LCS uncemented, unconstrained mobile | 675 | 2.16 | 0.82 | (−0.29 to 1.92) | Non-inferiority not shown | 0.073 |
| (TKR) Maxim cemented, posterior-stabilised fixed | 282 | 3.24 | 1.90 | (−0.02 to 3.82) | Non-inferiority not shown | 0.026 |
| (TKR) Maxim cemented, unconstrained fixed | 629 | 2.34 | 1.00 | (−0.16 to 2.15) | Non-inferiority not shown | 0.045 |
| (TKR) NRG cemented, posterior-stabilised fixed | 1784 | 2.24 | 0.90 | (0.22 to 1.58) | Non-inferiority not shown | 0.005 |
| (TKR) NRG cemented, unconstrained fixed | 2350 | 1.79 | 0.44 | (−0.11 to 1.00) | Non-inferiority not shown | 0.059 |
| (TKR) Natural Knee II cemented, unconstrained fixed | 1183 | 2.34 | 1.00 | (0.15 to 1.84) | Non-inferiority not shown | 0.010 |
| (TKR) NexGen cemented, posterior-stabilised mobile | 414 | 3.39 | 2.04 | (0.49 to 3.60) | Inferior by ≥20% | 0.005 |
| (TKR) NexGen cemented, posterior-stabilised fixed | 16 989 | 2.30 | 0.95 | (0.56 to 1.34) | Inferior by ≥20% | <0.001 |
| (TKR) NexGen cemented, unconstrained fixed | 12 603 | 1.47 | 0.13 | (−0.25 to 0.51) | Non-inferiority not shown | 0.253 |
| (TKR) NexGen hybrid, unconstrained fixed | 454 | 1.72 | 0.37 | (−0.79 to 1.54) | Non-inferiority not shown | 0.266 |
| (TKR) NexGen uncemented, posterior-stabilised fixed | 514 | 2.66 | 1.31 | (0.10 to 2.52) | Non-inferiority not shown | 0.017 |
| (TKR) NexGen uncemented, unconstrained fixed | 1421 | 3.25 | 1.90 | (0.98 to 2.83) | Inferior by ≥20% | <0.001 |
| (TKR) Optetrak cemented, posterior-stabilised fixed | 746 | 5.29 | 3.94 | (2.45 to 5.44) | Inferior by ≥100% | <0.001 |
| (TKR) PFC Sigma Bicondylar Knee cemented, posterior-stabilised mobile | 2280 | 2.92 | 1.57 | (0.90 to 2.24) | Inferior by ≥20% | <0.001 |
| (TKR) PFC Sigma Bicondylar Knee cemented, posterior-stabilised fixed | 23 690 | 2.03 | 0.69 | (0.31 to 1.06) | Inferior by ≥20% | <0.001 |
| (TKR) PFC Sigma Bicondylar Knee cemented, unconstrained fixed | 51 762 | 1.61 | 0.27 | (−0.09 to 0.63) | Non-inferiority not shown | 0.071 |
| (TKR) PFC Sigma Bicondylar Knee cemented, unconstrained mobile | 2852 | 2.72 | 1.37 | (0.73 to 2.01) | Inferior by ≥20% | <0.001 |
| (TKR) PFC Sigma Bicondylar Knee hybrid, unconstrained fixed | 771 | 1.75 | 0.40 | (−0.54 to 1.34) | Non-inferiority not shown | 0.202 |
| (TKR) PFC Sigma Bicondylar Knee uncemented, unconstrained mobile | 254 | 1.60 | 0.25 | (−1.07 to 1.57) | Non-inferiority not shown | 0.355 |
| (TKR) PFC Sigma Bicondylar Knee monobloc polyethylene tibia | 1486 | 1.61 | 0.27 | (−0.27 to 0.80) | Non-inferiority not shown | 0.163 |
| (TKR) Profix cemented, unconstrained fixed | 454 | 2.58 | 1.23 | (−0.19 to 2.66) | Non-inferiority not shown | 0.045 |
| (TKR) Profix Oxinium monobloc polyethylene tibia | 317 | 3.58 | 2.24 | (0.22 to 4.26) | Non-inferiority not shown | 0.015 |
| (TKR) Profix uncemented, unconstrained fixed | 1055 | 1.81 | 0.47 | (−0.36 to 1.29) | Non-inferiority not shown | 0.134 |
| (TKR) Profix monobloc polyethylene tibia | 371 | 1.47 | 0.13 | (−1.09 to 1.34) | Non-inferiority not shown | 0.420 |
| (TKR) Rotaglide+ cemented, unconstrained mobile | 845 | 3.08 | 1.74 | (0.58 to 2.89) | Inferior by ≥20% | 0.002 |
| (TKR) Rotaglide cemented, unconstrained mobile | 487 | 2.65 | 1.31 | (0.04 to 2.58) | Non-inferiority not shown | 0.022 |
| (TKR) Scorpio cemented, posterior-stabilised mobile | 662 | 2.03 | 0.68 | (−0.39 to 1.76) | Non-inferiority not shown | 0.106 |
| (TKR) Scorpio cemented, posterior-stabilised fixed | 3175 | 2.01 | 0.67 | (0.09 to 1.25) | Non-inferiority not shown | 0.012 |
| (TKR) Scorpio cemented, unconstrained fixed | 5380 | 2.29 | 0.94 | (0.43 to 1.45) | Inferior by ≥20% | <0.001 |
| (TKR) Scorpio cemented, unconstrained mobile | 601 | 3.39 | 2.05 | (0.61 to 3.49) | Inferior by ≥20% | 0.003 |
| (TKR) Scorpio hybrid, unconstrained fixed | 565 | 1.95 | 0.60 | (−0.54 to 1.75) | Non-inferiority not shown | 0.152 |
| (TKR) Scorpio uncemented, unconstrained fixed | 1702 | 2.48 | 1.14 | (0.36 to 1.91) | Inferior by ≥20% | 0.002 |
| (TKR) TC Plus cemented, unconstrained fixed | 3820 | 2.19 | 0.84 | (0.28 to 1.40) | Inferior by ≥20% | 0.002 |
| (TKR) TC Plus cemented, unconstrained mobile | 2242 | 1.52 | 0.18 | (−0.41 to 0.76) | Non-inferiority not shown | 0.279 |
| (TKR) TC Plus uncemented, unconstrained mobile | 712 | 2.40 | 1.06 | (0.02 to 2.09) | Non-inferiority not shown | 0.023 |
| (TKR) Triathlon cemented, posterior-stabilised fixed | 2754 | 2.52 | 1.18 | (0.63 to 1.72) | Inferior by ≥20% | <0.001 |
| (TKR) Triathlon cemented, unconstrained fixed | 8378 | 2.07 | 0.72 | (0.32 to 1.12) | Inferior by ≥20% | <0.001 |
| (TKR) Triathlon uncemented, unconstrained fixed | 257 | 3.51 | 2.17 | (0.50 to 3.84) | Inferior by ≥20% | 0.005 |
| (TKR) Vanguard cemented, posterior-stabilised fixed | 665 | 2.87 | 1.53 | (0.71 to 2.35) | Inferior by ≥20% | <0.001 |
| (TKR) Vanguard cemented, unconstrained fixed | 4840 | 1.96 | 0.61 | (0.19 to 1.04) | Non-inferiority not shown | 0.002 |
| (UNI) AMC/Uniglide Unicondylar, fixed | 409 | 4.80 | 3.45 | (1.70 to 5.21) | Inferior by ≥100% | <0.001 |
| (UNI) AMC/Uniglide Unicondylar, mobile | 479 | 11.54 | 10.19 | (7.69 to 12.69) | Inferior by ≥100% | <0.001 |
| (UNI) MG Uni Unicondylar, fixed | 953 | 6.66 | 5.32 | (3.77 to 6.87) | Inferior by ≥100% | <0.001 |
| (UNI) Oxford Partial Knee Unicondylar, mobile | 13 555 | 6.58 | 5.23 | (4.74 to 5.72) | Inferior by ≥100% | <0.001 |
| (UNI) Physica ZUK Unicondylar, fixed | 1113 | 4.02 | 2.67 | (1.80 to 3.54) | Inferior by ≥100% | <0.001 |
| (UNI) Preservation Unicondylar, fixed | 480 | 12.12 | 10.78 | (8.04 to 13.52) | Inferior by ≥100% | <0.001 |
| (UNI) Sigma HP Unicondylar, fixed | 688 | 5.89 | 4.55 | (3.35 to 5.75) | Inferior by ≥100% | <0.001 |
| (UNI) Sled Unicondylar, fixed | 325 | 8.48 | 7.13 | (4.41 to 9.85) | Inferior by ≥100% | <0.001 |
TKR, total knee replacement; UNI, unicondylar knee replacement.