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. 2019 Apr 23;9(4):e026527. doi: 10.1136/bmjopen-2018-026527

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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Plasma levels of HBP, PCT, CRP, WBC and neutrophils, as well as the SOFA Score, at enrolment. Each dot represents the HBP level (A), PCT level (B), SOFA Score (C) in an individual plasma sample at enrolment. (D–F) show the CRP level (D), WBC count (E) and neutrophil count (F) at enrolment among the healthy group, local infection group, sepsis (non-shock) group and septic shock group. Single-factor analysis was used for comparisons the differences among the indicators of the four groups, each two comparisons using Tamhane’s T2 method, and p values are given. Comparison between the survival and non-survival groups using independent sample T test. Star symbols indicate a significant difference, * indicates p<0.05, ** indicates p<0.01. CRP, C reactive protein; HBP, heparin-binding protein; PCT, procalcitonin; WBC, white blood cell.