Table 5.

International Prognostic Scoring System-Revised (IPSS-R)

Variables	Score
	0	0.5	1	1.5	2	3	3
Karyotype*	Very favourable		Favourable	-	Intermediate	Unfavourable	Very unfavourable
% Blasts	0-2	-	3-4	-	5-10	>10	-
hemoglobin	≥10		8-9	<8	-	-	-
Platelets	≥100	50-99	<50	-	-	-	-
ANC	≥0.8	<0.8	-	-	-	-	-
Risk Groups
SCORE <1.5 = Very low (median of survival 9.3 years - risk of leukemic evolution rare)
SCORE 2-3 = Low (median of survival 6.3 years - risk of leukemic evolution 25% at 10.8 years)
SCORE 4-4.5 = Intermediate (median of survival 3.4 years - risk of leukemic evolution 25% at 3.2 years) SCORE 5-6 = High (median of survival 1.2 years - risk of leukemic evolution 25% at 1.4 years)
SCORE >6 = Very High (median of survival 0.6 years - risk of leukemic evolution 25% at 0.7 years)
*Very favourable: Y, del(11q)
*Favourable: normal, del(5q), del(12q), double change that includes del(5q)
*Intermediate: del(7q), +8, +17, i(17q), other abnormalities;
*Unfavourable: complex karyotype (3 abnormalities), double change that includes -7/del(7q); inv(3)/t(3q)/del(3q),
* Very unfavourable: complex karyotype (>3 abnormalities)