Table 4.

Most common food additives and their adverse reactions in children.

Food colorants
Carmine	Recurrent intermittent flares of atopic eczema (11, 18)
Annatto	Urticaria/angioedema (19, 20)
Tartrazine	Recurrent intermittent flares of atopic eczema (24) Chronic Urticaria (22, 23) Fixed drug eruption (25) Irritability, restlessness and sleep disturbance (27)
Spices	Angioedema and anaphylaxis (29; 30; 31) Exacerbations of AE (32).
Saffron	Allergic rhinitis (33)
Preservatives
Butylated Hidroxyanisole, Butylated Hydroxytoluene Sulfites	No studies in children. Bronchoconstriction (43, 44) Urticaria and anaphylaxis (45)
Sweeteners
Aspartame	SCD (47) Chronic headache (not confirmed in children) (48, 49, 50) Early menarche (51).
Monosodium glutamate	CIU (22, 58)