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. 2019;90(Suppl 3):66–79. doi: 10.23750/abm.v90i3-S.8167

Table 2.

Most frequently reported drugs causing DRESS syndrome in children

Single case or less than 10 children (mean age 7,6 years) (46-114)

  • carbamazepine 14/103 (13.6%)

  • phenytoin 12/103 (11.7%)

  • phenobarbital 9/103 (8.8%)

  • valproic acid 6/103 (5.9%)

  • vancomycin 5/103 (5%)

  • lamotrigine 4/103 (4%)

  • cefotaxime 4/103 (4%)

  • trimethoprim-sulfamethoxazole 4/103 (4%)

  • ceftriaxone 3/103 (3%)

  • levetiracetam 3/103 (3%)

  • dapsone 3/103 (3%)

  • clindamycin 2/103 (2%)

  • piperacillin-tazobactam 2/103 (2%)

  • azithromycin 2/103 (2%)

  • oxacarbamazepine 2/103 (2%)

  • minocycline 2/103 (2%)

  • sulfadiazine 2/103 (2%)

  • oxacilline 2/103 (2%)

  • penicillin 2/103 (2%)

  • cefixime 1/103 (0.9%)

  • naproxen 1/103 (0.9%)

  • canakinumab 1/103 (0.9%)

  • amoxi-clav 1/103 (0.9%)

  • anakinra 1/103 (0.9%)

  • tobramycin 1/103 (0.9%)

  • ibuprofen 1/103 (0.9%)

  • acetylsalicylic acid 1/103 (0.9%)

  • griseofulvine 1/103 (0.9%)

  • sulthiame 1/103 (0.9%)

  • infliximab 1/103 (0.9%)

  • fluoxetina 1/103 (0.9%)

  • cefepime 1/103 (0.9%)

  • allopurinol 1/103 (0.9%)

  • perampanel 1/103 (0.9%)

  • cefditoren-pivoxil 1/103 (0.9%)

  • paracetamol 1/103 (0.9%)

  • Ethambutol+rifampin+pyranzinamide 1/103 (0.9%)

  • pyrimethamine 1/103 (0.9%)

  • rufinamide 1/103 (0.9%)
32 children (mean age 8,9 y) (13)

  • 13 carbamazepine

  • 12 phenytoin

  • 5 phenobarbital

  • 5 lamotrigine

  • 1 primidone

  • 1 oxcarbamazepine
33 children (mean age 5,8 y) (115)

  • 18 phenobarbital

  • 15 phenytoin
29 children (mean age 11 y) (116)

  • 10 trimethoprim-sulfamethoxazole

  • 3 phenytoin

  • 3 amoxicillin

  • 2 cefalosporins

  • 2 lamotrigine

  • 2 minocyclin

  • 2 macrolids

  • 2 oxcarbamazepine

  • 1 carbamazepine

  • 1 clindamycin

  • 1 zonisamide
11 children (mean age 6,6 y) (117)

  • 4 lamotrigine

  • 1 cefotaxime

  • 2 carbamazepine

  • 1 phenytoin + phenobarbital

  • 3 amoxi-clav
16 children (mean age 8,2 y) (45)

  • 3 amoxi-clav

  • 1 ampicillin-sulbactam

  • 2 cefdinir

  • 1 cefotaxime

  • 1 clarythromycin

  • 3 carbamazepine

  • 1 lamotrigine

  • 1 phenytoin

  • 1 phenobarbital

  • 1 sulfasalazine

  • 1 oxymetazoline nasal spray