Table 3.

Three proposed diagnostic criteria of DRESS syndrome

	Bocquet et al. (1)	RegiSCAR (7)	J-SCAR (129)
Requirement for diagnosis	≥3 criteria	≥3 criteria of the following asterisk marks	all 7 criteria = typical without 2 asterisk marks = atypical
History		- hospitalization - reaction suspected to be drug related	- symptoms persisting at least 2 weeks after drug discontinuation
Fever		- fever ≥38°C*	- fever ≥38°C
Cutaneous finding	- acute drug eruption	- acute rash	- macular rash developing 3 weeks after starting offending drug
Hematologic abnormalities	- eosinophilia >1.5×109/L or atypical lymphocytosis	one of the following hematologic abnormalities - eosinophilia over laboratory limits - lymphocyte count over and under normal limits - thrombocytopenia under laboratory limits	one of the following hematologic abnormalities - leucocytosis (>11×109 /L) - atypical lymphocytes (>5%) - eosinophilia (>1.5×109 /L)
Other organ involvements	- lymphadenopathy ≥2 cm in diameter - hepatitis with liver transaminases ≥2 times of the normal values - interstitial nephritis - interstitial pneumonitis - carditis	- lymphadenopathy involving ≥2 sites* - at least 1 internal organ involvement*	- lymphadenopathy* - liver abnormalities (ALT >100 U/L)
Viral reactivation			- HHV-6 reactivation*